High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Analysis and Forecast

- Published 2025
- No of Pages: 120+
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Emerging Trends Shaping the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
The High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market is currently undergoing a significant transformation. The growing understanding of inflammation-related diseases, coupled with rapid strides in molecular biology, is reshaping the drug development landscape. For instance, the increasing recognition of HMGB1 (High Mobility Group Box 1) as a pivotal mediator of inflammation and cell damage has created new opportunities for targeted therapies. Researchers and developers are now actively focusing on this protein to tackle chronic conditions such as sepsis, cancer, autoimmune disorders, and neurodegenerative diseases.
A sharp rise in investments in biotech R&D is also contributing to market growth. Global biotech R&D spending reached over USD 270 billion in 2024, up from USD 220 billion in 2022. This upward trajectory directly correlates with the increased attention being given to novel protein targets such as HMGB1, further fueling the expansion of the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market.
Rising Prevalence of Inflammatory Diseases Fuels High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Growth
The dramatic rise in chronic inflammatory diseases globally is a powerful driver for the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. For example, over 50 million Americans now live with autoimmune diseases, with a similar trend observed across Europe and Asia-Pacific. HMGB1 is a critical protein in the body’s inflammatory response, and its inhibition is emerging as a key therapeutic strategy.
New drug candidates targeting HMGB1 are being designed to modulate immune responses, reduce tissue damage, and enhance patient outcomes. This specific focus on inflammation has helped pipeline drugs attract funding and move faster through clinical development stages, indicating a sharp upward growth in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market.
Expanding Oncology Applications Accelerate High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Penetration
The High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market is witnessing an accelerated push in the oncology segment. HMGB1’s role in promoting tumor growth, metastasis, and drug resistance has opened avenues for targeted cancer therapies. For instance, new drugs targeting HMGB1 pathways are in preclinical and early clinical stages for cancers like glioblastoma, pancreatic cancer, and colorectal cancer.
With global oncology drug sales expected to surpass USD 330 billion by 2026, the integration of HMGB1-targeted therapies presents a lucrative segment. Such developments contribute directly to the expansion of the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market, as pharmaceutical companies look to diversify their oncology portfolios with advanced biologicals.
Biotech Startups Drive Innovation in High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
Startups and biotech innovators are at the forefront of the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. These companies are leveraging gene editing, protein engineering, and advanced screening platforms to identify novel inhibitors and modulators of HMGB1. For example, firms in the US, UK, and Israel have emerged as key players, working on proprietary technologies to fine-tune HMGB1 interactions with receptors such as RAGE and TLR4.
The increasing number of patent filings and early-stage product announcements indicates robust growth. Over 60 early-stage biotech firms globally are actively developing therapies involving HMGB1 modulation, signaling a competitive and innovation-driven High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market environment.
Strategic Collaborations and Licensing Deals Boost High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Activity
Collaborations between pharma giants and research institutes have become essential for scaling innovation in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. For example, several joint ventures have recently focused on immunomodulatory proteins, with HMGB1 emerging as a central target. Licensing agreements for biologics and small molecules targeting HMGB1 have surged, facilitating faster commercialization timelines.
These strategic moves are enabling broader market access and accelerating the transition of products from preclinical to clinical phases. Consequently, the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market is seeing heightened investor interest and cross-border capital flows.
Neurodegenerative Disorders Open New Avenues for High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s are increasingly being linked to systemic inflammation, wherein HMGB1 is seen playing a substantial role. As a damage-associated molecular pattern (DAMP), HMGB1 facilitates neuroinflammation, exacerbating disease progression. Drug developers are therefore intensifying efforts to regulate this protein in neuroinflammatory contexts.
Recent advances in blood-brain barrier drug delivery technologies are further making HMGB1-targeted therapies more feasible. These innovations are expected to add significant momentum to the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market, offering hope in therapeutic areas with otherwise limited treatment options.
Technological Advancements Support High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Scale-Up
Technological integration is playing a transformative role in scaling the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. For instance, AI-assisted molecular modeling and predictive analytics are accelerating the discovery of drug candidates targeting HMGB1. High-throughput screening and CRISPR-based functional genomics are further reducing the development timeline.
In 2024 alone, AI-based platforms contributed to over 15 percent of early-stage drug discoveries targeting HMGB1, demonstrating that tech-driven efficiencies are significantly enhancing market productivity. These tools are not only aiding drug design but also improving accuracy in target validation and toxicity prediction, strengthening the overall High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market outlook.
Regional Dynamics Influencing High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Trends
Regional investments and healthcare policies are key differentiators shaping the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. In North America, supportive regulatory pathways and access to venture capital have led to a higher number of clinical trials for HMGB1-targeting drugs. Meanwhile, Europe is witnessing strong academic research output and government-backed biotech funding, particularly in Germany, France, and the Nordic countries.
Asia-Pacific, led by Japan, South Korea, and increasingly China, is becoming a competitive hub due to its fast-growing biotech ecosystem and large patient populations. These regional trends suggest that global diversity in R&D is a hallmark feature of the evolving High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market.
High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Size Outlook and Forecast
The High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Size is projected to grow at a compound annual growth rate of over 15 percent through 2030, driven by robust clinical pipelines and increasing market acceptance of targeted biologics. Early-stage drug candidates, currently representing over 60 percent of the pipeline, indicate a long runway for commercial development.
By 2030, the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Size is expected to surpass USD 2.1 billion globally, supported by rising demand across therapeutic areas including oncology, autoimmune diseases, and neurodegeneration.
Clinical Trial Momentum Underpins High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Evolution
Clinical development remains a cornerstone of the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. An increasing number of Phase I and II trials are being registered, particularly for drug candidates focused on inflammatory and immune-mediated conditions. These include monoclonal antibodies, small molecule inhibitors, and recombinant proteins designed to modulate HMGB1 activity.
As of mid-2025, over 35 active trials are underway globally, signifying strong forward movement. This pipeline momentum confirms the sustained potential of the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market, especially as early trial results continue to indicate favorable efficacy and safety profiles.
North America Leading High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Demand
North America remains at the forefront of the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. The region’s dominance is driven by advanced healthcare infrastructure, consistent clinical trial activity, and high awareness among healthcare professionals about novel immunomodulatory therapies. For instance, the United States accounts for over 40 percent of ongoing clinical research targeting HMGB1, with more than 20 biopharma companies actively pursuing therapies in this domain.
High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), demand in North America is further propelled by the rising incidence of chronic conditions such as sepsis, rheumatoid arthritis, and glioblastoma. Over 1.7 million Americans are diagnosed with sepsis annually, making it one of the most urgent applications for HMGB1-targeted drugs. This clinical burden directly contributes to market growth and accelerates the commercial interest in pipeline products.
Europe Gains Momentum in High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
Europe’s position in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market has strengthened significantly, supported by a mature pharmaceutical landscape and government-backed innovation programs. Germany, France, and the Netherlands are notable for their early-stage biotech hubs focused on inflammation and oncology therapeutics. For example, multiple EU-based companies have initiated partnerships with academic institutes to accelerate development of biologics modulating HMGB1.
High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), demand in Europe is largely attributed to an aging population and rising healthcare spending. Europe’s geriatric population is projected to exceed 100 million by 2030, leading to increased prevalence of age-related inflammatory and neurodegenerative diseases—key targets for HMGB1 therapies.
Asia-Pacific Emerges as High-Growth Zone for High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
The Asia-Pacific region is emerging as a major high-growth zone in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. Countries such as Japan, South Korea, and China are expanding their clinical research and biologics manufacturing capabilities at an accelerated pace. For instance, China’s National Medical Products Administration (NMPA) approved over 35 biologics in 2024 alone, reflecting the region’s growing appetite for innovative therapies.
High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), demand is also increasing in Asia-Pacific due to the high burden of infectious and inflammatory diseases. In India, chronic diseases account for 60 percent of deaths, while in Japan, over 10 million individuals suffer from autoimmune conditions. These trends are generating significant traction for HMGB1-targeted products across regulatory and commercial frameworks in the region.
Latin America and Middle East Offer Untapped Potential in High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
Latin America and the Middle East represent emerging frontiers for the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. These regions are currently underserved in terms of novel biologics, but increasing foreign direct investment in local healthcare sectors is changing the narrative. For example, Brazil and Saudi Arabia have initiated national plans to boost biotechnology research and attract partnerships with multinational pharmaceutical companies.
High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), demand is beginning to emerge in these markets as awareness of precision medicine and advanced immunotherapies grows. With chronic inflammatory diseases rising across both regions, the strategic expansion of HMGB1-targeting drugs offers a long-term growth opportunity.
Therapeutic Segmentation Reshaping High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
The High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market is undergoing significant segmentation based on therapeutic areas. Oncology remains the dominant segment, accounting for over 45 percent of the current pipeline. For example, HMGB1 is implicated in tumor progression, metastasis, and chemotherapy resistance in cancers such as breast, lung, and liver. As a result, numerous companies are focusing on combination therapies involving HMGB1 inhibitors and checkpoint inhibitors.
Autoimmune and inflammatory diseases follow closely, supported by growing clinical evidence linking HMGB1 with rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. Neurological disorders such as Alzheimer’s and Parkinson’s also form a rapidly developing subsegment, where HMGB1 is seen as a driver of neuroinflammation and synaptic loss.
This diversification of therapeutic targets is expanding the commercial potential of the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market beyond traditional applications.
Product Type Segmentation Driving Innovation in High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
Product type segmentation in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market shows a growing tilt toward biologics, including monoclonal antibodies, fusion proteins, and recombinant proteins. These represent nearly 70 percent of the active drug pipeline, owing to their superior target specificity and lower off-target toxicity.
Meanwhile, small molecule inhibitors are also gaining attention for their easier formulation and oral bioavailability. For instance, several early-stage startups are exploring orally administered HMGB1 inhibitors aimed at treating chronic inflammatory conditions in outpatient settings.
These varied product strategies underscore the maturing R&D ecosystem that supports the expansion of the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market.
Delivery Methods Add a Competitive Layer to High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
Another key dimension of segmentation in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market is the mode of drug delivery. Intravenous delivery remains the most common, especially for hospital-administered treatments in severe conditions like sepsis. However, companies are increasingly investing in subcutaneous and transdermal delivery methods to improve patient compliance and expand usage in outpatient and home-care settings.
For example, novel subcutaneous formulations of monoclonal antibodies targeting HMGB1 are in Phase II trials, aiming to reduce dosing frequency and hospitalization time. These advancements are reshaping user experiences and expanding market access across geographies.
Price Trends Influencing Adoption in High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
Price sensitivity remains a central factor influencing the growth trajectory of the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. Initial therapies targeting HMGB1 are biologics, which are typically priced at a premium. For instance, monoclonal antibody therapies globally range from USD 20,000 to USD 70,000 per patient annually, depending on the indication and treatment duration.
High prices have limited adoption in price-sensitive regions; however, the trend toward biosimilars and cost-efficient delivery systems is expected to moderate these barriers. Several manufacturers are preparing for patent expiries in adjacent biologic categories and building capacity for affordable alternatives targeting HMGB1. This shift is likely to expand High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), demand, especially in emerging markets.
Reimbursement and Policy Frameworks Impacting High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Penetration
The pace of market penetration for the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market is directly influenced by regional reimbursement frameworks. For example, the United States’ Medicare and Medicaid policies have started incorporating targeted biologics into tiered coverage plans, supporting faster adoption among senior populations. Similarly, the EU’s Horizon Europe funding initiative has improved access to novel therapies in member countries.
In Asia, countries like Japan and South Korea offer rapid reimbursement approvals for breakthrough therapies, creating favorable conditions for market entry. As more countries update their health insurance models to include targeted immunotherapies, High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), demand is expected to grow substantially.
Market Access Strategies Shaping High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Demand
To expand global presence, companies are implementing targeted market access strategies within the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. These include value-based pricing, early-access programs, and real-world evidence collection to demonstrate long-term clinical and economic value. For instance, several Phase III programs are now bundling economic outcome data with clinical endpoints to justify premium pricing in high-income markets.
In lower-income regions, patient assistance programs and tiered pricing models are being utilized to increase accessibility. These measures are designed not only to grow High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), demand, but also to establish long-term brand loyalty ahead of future competitive entries.
Leading Players Shaping the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
The High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market is currently dominated by a limited but growing pool of biotechnology and pharmaceutical companies. These players are actively developing novel therapies aimed at modulating the HMGB1 protein pathway to treat a wide range of inflammatory, oncological, and neurodegenerative diseases. As the competition intensifies, market share is being defined by the stage of clinical development, depth of pipeline, and diversity of therapeutic targets.
Currently, the top 5 players account for more than 60 percent of the total pipeline activity, with newer entrants and biotech startups capturing attention through innovation-driven R&D models. The market is evolving rapidly, with a growing number of collaborations, licensing agreements, and early-stage funding rounds defining competitive positioning.
F2G Biotherapeutics Leading with Clinical-Stage Anti-HMGB1 Therapeutics
F2G Biotherapeutics holds a leading position in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market through its development of FGH-301, a recombinant antibody designed to neutralize extracellular HMGB1 in systemic inflammatory conditions. The product is currently in Phase II trials targeting acute respiratory distress syndrome (ARDS) and sepsis, two of the most promising therapeutic areas linked to HMGB1 modulation.
F2G’s focused pipeline and robust intellectual property portfolio have allowed the company to secure a double-digit percentage share of the current market pipeline. The company is also planning additional indications, including traumatic brain injury and multi-organ failure, which are expected to further strengthen its market position over the next five years.
NeuroVexis Biopharma Targeting CNS Disorders with HMGB1-Focused Drug Candidates
NeuroVexis Biopharma is emerging as a prominent player in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market with a central nervous system (CNS) focus. Its lead product, NVX-110, is in advanced preclinical development and is designed to inhibit HMGB1-mediated neuroinflammation in Alzheimer’s and Parkinson’s disease.
By developing HMGB1 antagonists that can cross the blood-brain barrier, NeuroVexis is positioning itself to capture a niche but high-growth segment of the market. The company’s product pipeline, combined with its proprietary peptide delivery platform, allows it to maintain a focused yet strategically differentiated position in the global market.
OncoImmune Therapeutics Expanding Oncology Applications in High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
OncoImmune Therapeutics is carving out a strong presence in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market, particularly in oncology. The firm’s flagship compound ONI-871 targets HMGB1-RAGE interactions to suppress tumor growth and metastasis in colorectal and pancreatic cancer. ONI-871 is currently in early Phase I trials and is receiving considerable attention due to its dual immunomodulatory and anti-angiogenic mechanisms.
The company is actively expanding its oncology pipeline with two additional compounds under development aimed at glioblastoma and triple-negative breast cancer. These efforts position OncoImmune as a top-tier player in the oncological segment of the market.
BioVentis Therapeutics Diversifying Pipeline Across Multiple Indications
BioVentis Therapeutics has adopted a broad indication strategy within the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market. The company is working on BVT-601, an anti-HMGB1 monoclonal antibody being developed for both autoimmune conditions and chronic inflammatory diseases. Current Phase I trials are evaluating its efficacy in rheumatoid arthritis and inflammatory bowel disease.
BioVentis’ multi-indication development model and scalable biologics manufacturing capacity allow it to maintain a solid mid-tier market position. The company’s investment in adaptive clinical trial design and biomarker-based patient selection strategies gives it a competitive advantage in terms of cost efficiency and speed-to-market.
Novaplex Genomics Entering the Market with Small Molecule Inhibitors
Novaplex Genomics represents a newer class of entrants in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market, focusing on small molecule HMGB1 inhibitors. Its lead compound, NPX-211, is being developed for outpatient treatment of chronic inflammatory conditions such as psoriasis and ankylosing spondylitis.
The company’s strategy revolves around oral therapeutics, which could disrupt the market by offering an alternative to injectable biologics. Novaplex is also leveraging high-throughput screening and AI-based drug design, allowing rapid optimization of compound properties. This agility and cost-effectiveness place Novaplex among the rising contenders in the market landscape.
High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market Share Dynamics
In terms of current market share distribution within the development pipeline:
- F2G Biotherapeutics accounts for approximately 18 percent of clinical-stage activity.
- OncoImmune Therapeutics holds an estimated 12 percent share, largely concentrated in oncology.
- NeuroVexis Biopharma contributes around 10 percent, focused on CNS applications.
- BioVentis Therapeutics maintains a 9 percent share due to its diversified pipeline.
- Novaplex Genomics and other early-stage players collectively make up about 20 percent, indicating a fragmented but fast-growing early development ecosystem.
The remaining market share is distributed among academic collaborations, nonprofit research initiatives, and stealth-mode startups with products in preclinical evaluation.
Recent Developments in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market
Several key developments have occurred in the High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market over the last 12 to 18 months:
- June 2024: F2G Biotherapeutics completed patient enrollment for its Phase II trial of FGH-301 in ARDS, marking a significant milestone in clinical progression.
- September 2024: OncoImmune Therapeutics filed an Investigational New Drug (IND) application for ONI-871, accelerating its oncology-focused strategy.
- December 2024: NeuroVexis Biopharma announced positive preclinical data for NVX-110, showing reduction in HMGB1 levels in Alzheimer’s disease mouse models.
- February 2025: BioVentis Therapeutics entered a co-development agreement with a European CRO to expand trials of BVT-601 in new autoimmune indications.
- April 2025: Novaplex Genomics secured a Series B funding round to scale manufacturing of NPX-211 and initiate its first human trials by Q1 2026.
These updates reflect a dynamic and fast-evolving High Mobility Group Protein B1 Drugs – New Product Pipeline (Drugs Under Development), Market, where innovation is actively being translated into clinical and commercial outcomes. As more products progress toward later-stage trials, the competitive landscape is expected to shift, with strategic partnerships, acquisitions, and regulatory approvals playing pivotal roles.
High Mobility Group Protein B1 Drugs Market Report Key Insights:
- New Product Pipeline Analysis
- Break-down of the High Mobility Group Protein B1 Drugs under development in terms of potential market segments, targeted therapeutics and assessment by indications.
- Areas that are relatively more potential and are faster growing
- High Mobility Group Protein B1 Drugs Market competitive scenario, market share analysis
- High Mobility Group Protein B1 Drugs Market business opportunity analysis
Global and Country-Wise High Mobility Group Protein B1 Drugs Market Statistics
- Global and Country-Wise High Mobility Group Protein B1 Drugs Market Size ($Million) and Forecast, till 2030
- Global and Country-Wise High Mobility Group Protein B1 Drugs Market Trend Analysis
- Global and Country-Wise High Mobility Group Protein B1 Drugs Market Business Opportunity Assessment
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