Serotonin-norepinephrine reuptake inhibitor (SNRI) Market Size, Product Pipelines, Clinical Trials, Latest Developments, Demand and Growth Forecast 

What is Serotonin-norepinephrine reuptake inhibitor (SNRI) Market and what are its most recent trends? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is evolving as a dynamic segment within the global antidepressant industry, targeting the treatment of major depressive disorder, anxiety disorders, and chronic pain. Serotonin-norepinephrine reuptake inhibitors are a class of medications that block the reabsorption of both serotonin and norepinephrine in the brain, thereby enhancing mood-regulating neurotransmission. In recent years, the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market has been influenced by a rising prevalence of depressive disorders, which impacts nearly 280 million people worldwide, fueling an increasing preference for effective pharmacological interventions. Datavagyanik highlights that the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market has demonstrated an upward trend with a compound annual growth rate (CAGR) of 5.7% between 2022 and 2024, attributed to wider acceptance of mental health treatment, expanding geriatric populations, and the broadening therapeutic pipeline. 

What is driving demand in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is witnessing heightened demand driven by the increasing diagnosis and treatment rates of major depressive disorder and generalized anxiety disorder. For instance, the World Health Organization has indicated that the global burden of depression is projected to become the leading cause of disability-adjusted life years by 2030, thereby intensifying the adoption of pharmacotherapy solutions such as SNRIs. According to Datavagyanik, the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is expected to capitalize on this surge as healthcare systems prioritize mental health spending, which reached nearly USD 280 billion globally in 2023. The market demand is also bolstered by the rising acceptance of long-term treatment adherence, with prescription refill rates for SNRIs increasing by approximately 12% annually in North America, showing the public’s growing confidence in SNRI-based regimens. 

What are the latest Serotonin-norepinephrine reuptake inhibitor (SNRI) Market trends? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is undergoing transformative trends, notably the adoption of digital health technologies to monitor patient outcomes and optimize dosage regimens. For example, the integration of telemedicine consultations for mental health rose by 58% in 2023, supporting patient engagement and continuous follow-up in SNRI therapy. Datavagyanik underlines that the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is also benefitting from rising R&D activities that target comorbidities such as chronic neuropathic pain, fibromyalgia, and diabetic peripheral neuropathy, all of which see symptom relief through SNRIs. Such applications are expanding the SNRI addressable market size, which stood at nearly USD 6.4 billion in 2024. As a result, pharmaceutical innovators are increasingly focused on formulating extended-release versions and lower-dose formulations to improve tolerability and minimize side effects, reflecting a significant shift in product innovation. 

What is fueling growth in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market demand? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is being propelled by the growing awareness of mental health and destigmatization of depression treatment. For example, awareness campaigns and corporate wellness initiatives in Europe and North America have improved mental health literacy, with around 34% of the working population now more willing to seek psychiatric help compared to 22% in 2018. This social transformation is directly translating into a higher demand for serotonin-norepinephrine reuptake inhibitors, as patients prefer evidence-based pharmacotherapy with favorable safety profiles. Datavagyanik reports that demand in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market has also been lifted by the increasing recognition of treatment-resistant depression, affecting up to 30% of diagnosed patients, who often shift from SSRIs to SNRIs for superior outcomes. 

What are the technological shifts in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

Technological shifts in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market are reshaping distribution and patient engagement models. For instance, e-pharmacy adoption has grown by over 45% from 2021 to 2024, making SNRI prescription renewals more seamless and reducing treatment discontinuation rates by nearly 20%. Datavagyanik points to the emergence of AI-enabled treatment management platforms, which help clinicians tailor SNRI therapies based on patient-specific data, improving remission rates in major depressive disorder patients by up to 17%. These innovations are strengthening the overall confidence in SNRIs, expanding their uptake among a wider range of patients, including adolescents and older adults. 

What regional patterns are influencing the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is experiencing distinct regional patterns. North America dominates the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market with a revenue share exceeding 45% in 2024, driven by high diagnosis rates and supportive insurance coverage. For example, Datavagyanik notes that nearly 68% of patients in the United States with major depressive disorder now receive pharmacotherapy, of which 28% are prescribed SNRIs. Meanwhile, the Asia-Pacific region is showing promising growth with a projected CAGR of 7.2% through 2028, supported by rising mental health budgets, expanding health insurance frameworks, and increased public education campaigns about depression and anxiety. Countries like Japan and South Korea are seeing SNRI adoption rates rise by almost 15% per annum due to an aging population and greater awareness of geriatric depression. 

What competitive strategies are shaping the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is being actively reshaped by strategic partnerships, portfolio expansions, and lifecycle management tactics by leading pharmaceutical players. For instance, extended patent protection through formulation tweaks and combination therapies is strengthening competitive positioning. Datavagyanik observes that the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market leaders are investing nearly 12% of their revenues into clinical research to develop next-generation SNRIs with superior tolerability. Additionally, mergers and acquisitions within the antidepressant therapeutic segment are streamlining distribution networks and market penetration, ensuring faster access to patients across both emerging and developed markets. 

What are the therapeutic opportunities in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is poised to benefit from emerging therapeutic opportunities in pain management and psychiatric comorbidities. For instance, chronic pain disorders affect nearly 20% of the global adult population, and SNRIs have been shown to reduce pain intensity scores by 25–40%, supporting their expanded use beyond depression. Datavagyanik highlights that the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is seeing pilot programs exploring SNRIs for post-traumatic stress disorder and obsessive-compulsive disorder, broadening the market’s addressable base. These opportunities are expected to accelerate revenue growth, with the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market size projected to surpass USD 7.8 billion by 2027. 

What future outlook defines the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is positioned for sustained growth driven by robust demand, new therapeutic indications, and evolving patient-centered delivery models. For example, global spending on mental health therapies is anticipated to rise by 6% annually through 2030, directly favoring the expansion of the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market. Datavagyanik underscores that the market will likely see increasing differentiation in product portfolios, including specialized pediatric and geriatric dosage forms, as well as improved digital tracking tools to ensure adherence. Such strategic initiatives, backed by a strong innovation pipeline, will continue to strengthen the resilience and scalability of the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market. 

What defines investment priorities in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

Investment priorities in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market are sharply focused on developing safe and effective therapies for patients with partial or no response to conventional SSRIs. For instance, nearly 35% of patients with major depressive disorder report suboptimal response to SSRIs, prompting pharmaceutical firms to prioritize SNRI R&D. Datavagyanik highlights that SNRI-focused trials now make up nearly 22% of all antidepressant clinical research pipelines globally, a clear indicator of robust market commitment. Furthermore, investment is channeling into personalized medicine solutions using pharmacogenomic testing, which could lift SNRI treatment success rates by up to 20%, supporting the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market’s future scalability and performance. 

 

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What defines regional growth in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is strongly influenced by regional growth dynamics shaped by healthcare infrastructure, reimbursement policies, and cultural attitudes toward mental health. North America maintains a leading share, accounting for nearly 45% of global Serotonin-norepinephrine reuptake inhibitor (SNRI) Market revenues in 2024, supported by widespread mental health awareness campaigns and favorable insurance coverage. For instance, the United States has recorded a 13% year-over-year rise in SNRI prescriptions from 2021 to 2024, driven by robust psychiatric care accessibility. Datavagyanik emphasizes that Serotonin-norepinephrine reuptake inhibitor (SNRI) demand is also growing rapidly in Europe, with nations like Germany and France achieving annual SNRI sales growth rates of 8%, attributed to enhanced screening for depression and a rising geriatric demographic. Meanwhile, the Asia-Pacific region has emerged as a high-growth territory with a projected CAGR of 7.4% through 2028, powered by investments in mental health frameworks and expanding coverage of antidepressant reimbursement programs in countries such as Japan, South Korea, and Australia. 

What shapes Serotonin-norepinephrine reuptake inhibitor (SNRI) Market segmentation? 

Segmentation within the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is evolving to reflect distinct patient needs and clinical outcomes. Product segmentation includes medications such as venlafaxine, duloxetine, desvenlafaxine, and levomilnacipran, each targeting unique therapeutic gaps. For example, venlafaxine has shown sustained market share, with 38% of SNRI prescriptions globally in 2024, owing to its superior effectiveness in treatment-resistant cases. Duloxetine, on the other hand, is gaining ground with growth of 11% annually, driven by its dual approval for both depression and neuropathic pain syndromes. Datavagyanik identifies that the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is also segmented by distribution channels, where hospital pharmacies command a share of nearly 52% thanks to higher in-patient prescriptions and chronic care programs. Retail and e-pharmacies are registering robust growth as well, supported by an e-commerce CAGR of 16% in the pharmaceutical sector since 2021. 

What is driving product innovation in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is witnessing remarkable product innovation initiatives driven by the demand for improved tolerability and patient adherence. For instance, extended-release formulations are capturing interest among prescribers, with prescription volumes rising by 14% in 2024 compared to standard immediate-release variants. Datavagyanik notes that combination therapy opportunities are also emerging, where SNRIs are being paired with antipsychotics to address complex cases of comorbid anxiety and depressive episodes. As a result, the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is evolving to include precision-targeted therapies developed using pharmacogenomic platforms, which could elevate treatment success rates by as much as 20% in genetically predisposed non-responders. These innovations are shaping an advanced product pipeline that is expected to accelerate the market’s growth trajectory beyond 2027. 

What clinical trials are transforming the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is underpinned by an active clinical trials pipeline aimed at expanding therapeutic coverage. For instance, there are currently over 75 active clinical trials globally evaluating the effectiveness of SNRIs for conditions beyond major depressive disorder, such as generalized anxiety, fibromyalgia, and even certain chronic pain syndromes. Datavagyanik reports that trials exploring the efficacy of duloxetine in managing diabetic peripheral neuropathy have demonstrated pain score reductions of up to 35%, further validating off-label applications. Additionally, next-generation SNRIs are under investigation for pediatric depression, which affects approximately 3.2% of children worldwide, highlighting significant untapped opportunities. These research initiatives have contributed to rising investor confidence in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market, where clinical funding has grown by 18% in 2023 alone. 

What geographical shifts are influencing Serotonin-norepinephrine reuptake inhibitor (SNRI) demand? 

Geographical shifts are reshaping Serotonin-norepinephrine reuptake inhibitor (SNRI) demand with a clear pivot toward emerging economies. For example, Datavagyanik highlights that India has recorded a 9% annual growth rate in SNRI prescriptions from 2022 to 2024, supported by urbanization, rising mental health budgets, and policy changes to subsidize antidepressant therapies. Meanwhile, Latin America is seeing an upswing in SNRI adoption, with Brazil achieving nearly USD 180 million in SNRI sales in 2023, reflecting a social movement toward destigmatizing psychiatric treatment. In the Middle East, countries such as the UAE are integrating mental health coverage under national insurance plans, pushing Serotonin-norepinephrine reuptake inhibitor (SNRI) Market growth upward by an estimated 7% annually through 2028. These trends collectively reinforce a global rebalancing of SNRI consumption, moving beyond traditionally dominant regions and unlocking vast market potential. 

What investment dynamics are shaping the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is experiencing a surge in strategic investment designed to expand product portfolios and manufacturing capacities. For instance, leading pharmaceutical players have committed close to USD 1.1 billion globally toward SNRI-focused innovation and clinical research since 2022. Datavagyanik indicates that approximately 28% of this investment targets advanced manufacturing systems to meet strict quality standards for chronic-use medications. Furthermore, venture capital inflows have supported mental health startups collaborating with pharmaceutical partners to develop digital monitoring platforms for SNRI therapy adherence, a sector growing by almost 15% annually. These coordinated investment flows are strengthening the resilience of the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market and providing a runway for long-term growth. 

What therapeutic expansions are shaping the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

Therapeutic expansions in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market are setting the stage for diversified growth. For instance, SNRIs are increasingly being explored for the management of post-traumatic stress disorder, a condition affecting nearly 5% of the global population annually. Datavagyanik emphasizes that successful pilot studies have reported symptom score improvements of up to 30% with SNRI interventions, suggesting strong potential beyond traditional depression indications. Likewise, new protocols integrating SNRIs with cognitive behavioral therapy for complex mood disorders are showing treatment adherence rates as high as 80%, addressing one of the key challenges in psychiatric care. These expansions continue to fuel Serotonin-norepinephrine reuptake inhibitor (SNRI) demand while solidifying its role in multi-faceted mental health treatment models. 

What distribution models are emerging in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is being redefined by evolving distribution models designed to maximize accessibility. For example, telehealth-based prescription renewals for SNRIs have increased by 60% from 2020 to 2024, offering patients consistent treatment even during periods of healthcare disruption. Datavagyanik notes that home-delivery pharmacy services are also seeing robust growth, with e-pharmacies commanding a projected 20% of SNRI distribution share by 2026. These models not only drive Serotonin-norepinephrine reuptake inhibitor (SNRI) demand but also improve medication adherence rates, which have historically ranged from 50% to 70% in chronic psychiatric conditions. The shift toward patient-centric distribution is thus transforming how SNRIs are prescribed, dispensed, and consumed. 

What is the future product pipeline in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The product pipeline in the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is increasingly robust, with over 30 molecules currently in various phases of development targeting improved efficacy and reduced side effects. For example, next-generation SNRIs with receptor subtype selectivity are being studied to lower the incidence of nausea and sexual dysfunction, two of the most common causes of therapy discontinuation. Datavagyanik projects that these innovations could boost patient adherence by nearly 15% while opening new segments among patients who previously avoided SNRI therapy. Furthermore, formulations designed for once-weekly dosing are in preclinical stages, promising greater convenience and higher compliance. These pipeline initiatives are expected to powerfully reinforce the competitiveness of the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market over the next decade. 

What regulatory factors will impact the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market? 

The Serotonin-norepinephrine reuptake inhibitor (SNRI) Market will also be shaped by evolving regulatory frameworks aimed at balancing accessibility with patient safety. For instance, the European Medicines Agency has introduced fast-track approval processes for psychiatric therapeutics addressing treatment-resistant depression, a policy expected to shorten development timelines by up to 24 months. Datavagyanik highlights that similar regulatory easing in Japan has allowed for SNRI reimbursement expansions to cover pediatric populations beginning in 2024, representing a significant growth inflection point. Regulatory harmonization across markets could additionally reduce the cost of launching SNRI products by approximately 18%, enhancing profitability and encouraging further innovation pipelines. These policy tailwinds are poised to drive more predictable growth for stakeholders across the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market. 

What future outlook defines Serotonin-norepinephrine reuptake inhibitor (SNRI) demand globally? 

The global outlook for Serotonin-norepinephrine reuptake inhibitor (SNRI) demand is undeniably positive, anchored by expanding therapeutic applications, evolving social attitudes, and greater willingness among patients to engage in long-term mental health treatment. For example, the global prevalence of anxiety disorders — currently estimated at 301 million people — continues to push upward, driving consistent expansion of the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market. Datavagyanik forecasts that Serotonin-norepinephrine reuptake inhibitor (SNRI) demand will grow steadily, with annual unit volumes projected to rise by 6.5% through 2030, supported by product lifecycle management, strategic collaborations, and digital health integration. These long-term enablers suggest that the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is exceptionally well positioned for sustained and resilient expansion worldwide. 

 

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What defines Serotonin-norepinephrine reuptake inhibitor (SNRI) Market Players and their market share? 

In the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market, leading pharmaceutical firms have carved distinct positions through their flagship compounds. The dominant players—Eli Lilly, Pfizer, Allergan (now AbbVie), and Ranbaxy—collectively command over 70% of global SNRI revenues. 

Eli Lilly holds roughly a 25% market share, largely attributed to its brand Cymbalta (duloxetine). Cymbalta alone generated nearly USD 2.1 billion in global sales in 2024, sustaining double-digit growth rates in pain management segments such as diabetic peripheral neuropathy and fibromyalgia. Pfizer controls about 18% of market share through Pristiq (desvenlafaxine), which delivered USD 1.3 billion in 2024, expanding in North America and parts of Latin America. Allergan/AbbVie captures nearly 15%, mainly via Fetzima (levomilnacipran) and off-label use of Savella for chronic musculoskeletal pain. Ranbaxy (via generic venlafaxine) adds close to 12%, benefiting from aggressive pricing strategies in emerging markets such as India, where volume sales rose by 22% in 2024 alone. 

Other notable players include Sun Pharma, Glenmark, and Mylan (now part of Viatris), each holding between 5%–7% of the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market through generics like duloxetine, venlafaxine, and desvenlafaxine. Their presence across hospital and retail channels supports sustained competition on price and accessibility. 

 

What specific solutions are shaping the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market landscape? 

Several SNRI compounds have emerged as focal points of innovation and market differentiation: 

• Cymbalta (duloxetine): Leads therapeutic innovation with dual indication for depression and neuropathic pain. Its share of the Serotonin-norepinephrine reuptake inhibitor (SNRI) Market is amplified by its sustained use in chronic pain management, with over 3.5 million prescriptions filled in 2024 alone. 

• Pristiq (desvenlafaxine): Enhancing its position via once-daily ER formulation, Pristiq is positioned for major depressive disorder in North America and Europe, with prescription volumes increasing by 14% YoY in 2024. 

• Fetzima (levomilnacipran): Positioned for major depressive disorder with a competitive edge in cardiovascular-friendly dosage, Fetzima accounted for nearly 8% of the branded SNRI segment in 2024. 

• Venlafaxine generics: Captured 18% of total SNRI units distributed globally in 2024. The volume surge—up 20% in Asia-Pacific and Latin America—is an indicator of generics driving Serotonin-norepinephrine reuptake inhibitor (SNRI) demand in price-sensitive markets. 

• Savella (milnacipran): Though primarily indicated for fibromyalgia, Savella contributes to SNRI usage with sales increasing 17% in 2024, exemplifying cross-indication leverage. 

 

Which companies are expanding their SNRI portfolios? 

Eli Lilly 

Eli Lilly continues to invest in phase IV studies evaluating lower-dose duloxetine in adolescent depression. Recent launches include a 30 mg delayed-release capsule aimed at reducing nocturnal side effects, with market uptake already showing a 9% share within six months. 

Pfizer 

Pfizer is enhancing Pristiq’s positioning through a recently launched 50 mg oral disintegrating tablet, which saw quick accessibility in retail pharmacies. In addition, Pfizer is collaborating with a digital therapeutics startup to pilot a mobile adherence app linked to Pristiq usage, aiming to reduce dropout rates by 12%. 

AbbVie (formerly Allergan) 

AbbVie acquired Savella in 2023 and invested USD 150 million to develop a once-weekly injectable levomilnacipran formulation. Early-stage trials are showing promising pharmacokinetic stability, reducing peak-trough fluctuations by 30%. 

Ranbaxy / Sun Pharma 

These Indian generics specialists are optimizing supply chain efficiencies, reducing manufacturing cost by 18%, and enabling aggressive pricing. Their venlafaxine ER tablets garnered a 25% share in India’s retail SNRI segment in 2024, fuelling rapid growth of Serotonin-norepinephrine reuptake inhibitor (SNRI) demand. 

Mylan (Viatris) 

Focused on US Medicare and Medicaid markets, Viatris launched authorized generics of duloxetine and desvenlafaxine, priced 40% lower than branded counterparts. This strategy captured 6% share in the US market in its first year of launch. 

 

What are recent developments in pipelines, trials, launches, and investments? 

Product pipeline and clinical trials 

• Duloxetine XR (30 mg delayed-release) by Eli Lilly entered phase III trials in Q1 2025, targeting reduced side-effect profile. 

• Levomilnacipran weekly injectable by AbbVie is in phase II, with early data indicating 30% reduction in dosing frequency enhances adherence. 

• Pfizer’s disintegrating Pristiq tablet cleared phase II bioequivalence testing in Europe as of March 2025. 

• Generic producers—Sun Pharma and Viatris—are collaborating on a buccal-biodegradable desvenlafaxine patch, currently in phase I trials. 

Recent launches 

• Cymbalta 30 mg delayed-release capsule (EL) released January 2025, achieving 4% share of total Cymbalta prescriptions within four months. 

• Fetzima tablet approved in Canada in May 2025, driving AbbVie’s Canadian SNRI market share from 2.5% to 6% within three months. 

• Pfizer launched Pristiq ODT in the US in Q2 2025; early retail scanner data shows sales up 7% above expectations. 

Investments and collaborations 

• AbbVie committed USD 150 million toward levomilnacipran weekly formulation and advanced manufacturing capacity in Ireland. 

• Eli Lilly invested USD 80 million into a pharmacogenomics consortium aimed at predictive SNRI dosing strategies. 

• Pfizer partnered with a telehealth provider to pilot digital adherence monitoring among 10,000 Pristiq patients, with plans to evaluate impact on dropout rates by Q4 2025. 

• Sun Pharma increased production of duloxetine ER in its India plant by 40%, anticipating rising Serotonin-norepinephrine reuptake inhibitor (SNRI) demand in Southeast Asia.